Providing a comprehensive and critical review of the basic science and clinical aspects of the drug, this book covers the history and development of the drug and its current patterns of use and examines its basic pharmaceutical attributes and medicinal chemistry. The author discusses the properties of various formulations and discusses the pharmacokinetics of ibuprofen in animals and humans--highlighting the factors affecting absorption, distribution, metabolism, and elimination. Topics include: the clinical pharmacology and toxicology and the drug''s mechanisms of action in different disease states and conditions, the therapeutic uses in various acute and inflammatory conditions, and safety versus efficacy issues and the pharmacoepidemiological data.
Ibuprofen is widely used throughout the world for a variety of conditions. This reference work provides a comprehensive and critical review of the basic science and clinical aspects of the drug. The book begins with the history and development of the drug and its current patterns of use world- wide before moving on to examine its basic pharmaceutical attributes and medicinal chemistry. The properties of various formulations are described (oral prescription and OTC, topical and others) are described. The pharmacokinetics of ibuprofen in animals and humans is discussed - highlighting the factors affecting absorption, distribution, metabolism and elimination. The clinical pharmacology and toxicology and the drug''s mechanisms of action in different disease states and conditions are covered. The therapeutic uses in various acute and inflammatory conditions is detailed. Also considered are the safety versus efficacy issues and the pharmacoepidemiological data.
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