Multimodal therapy approaches that combine interventions aimed at different aspects of disease are emerging as potential—and perhaps essential—ways to enhance clinical outcomes for patients with psychiatric and neurological disorders. In order to examine the general principles underlying multimodal therapies and to explore challenges, potential barriers, and opportunities for their development, the National Academies of Sciences, Engineering, and Medicine convened a workshop in June 2016. Participants explored scientific, clinical, regulatory, and reimbursement issues related to multimodal approaches and potential opportunities to enhance clinical outcomes for individuals with nervous system disorders. This publication summarizes the presentations and discussions from the workshop. Table of ContentsFront Matter1 Introduction2 Multimodal Therapy: Overview of Principles, Barriers, and Opportunities3 Exploring the State of the Science4 Regulatory and Reimbursement Considerations5 Trial Designs to Establish Efficacy and Safety in Multimodal Therapies6 Developing Multimodal Therapies: Practical Considerations Relating to Industry7 Role of Research Funders in Multimodal Therapy DevelopmentAppendix A: ReferencesAppendix B: Workshop AgendaAppendix C: Registered Participants
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