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Assessment of Long-Term Health Effects of Antimalarial Drugs When Used for Prophylaxis

By: (Author) Board on Population Health and Public Health Practice , (Author) and Medicine National Academies of Sciences Engineering , (Author) Health and Medicine Division , (Edited by) Anne N. Styka , (Edited by) David A. Savitz

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Ksh 16,200.00

Format: Paperback or Softback

ISBN-10: 0309672104

ISBN-13: 9780309672108

Publisher: National Academies Press

Imprint: National Academies Press

Country of Manufacture: GB

Country of Publication: GB

Publication Date: Apr 24th, 2020

Print length: 426 Pages

Product Classification: Epidemiology & medical statistics
Medicine

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Among the many who serve in the United States Armed Forces and who are deployed to distant locations around the world, myriad health threats are encountered. In addition to those associated with the disruption of their home life and potential for combat, they may face distinctive disease threats that are specific to the locations to which they are deployed. U.S. forces have been deployed many times over the years to areas in which malaria is endemic, including in parts of Afghanistan and Iraq. Department of Defense (DoD) policy requires that antimalarial drugs be issued and regimens adhered to for deployments to malaria-endemic areas. Policies directing which should be used as first and as second-line agents have evolved over time based on new data regarding adverse events or precautions for specific underlying health conditions, areas of deployment, and other operational factorsAt the request of the Veterans Administration, Assessment of Long-Term Health Effects of Antimalarial Drugs When Used for Prophylaxis assesses the scientific evidence regarding the potential for long-term health effects resulting from the use of antimalarial drugs that were approved by FDA or used by U.S. service members for malaria prophylaxis, with a focus on mefloquine, tafenoquine, and other antimalarial drugs that have been used by DoD in the past 25 years. This report offers conclusions based on available evidence regarding associations of persistent or latent adverse events. Table of ContentsFront MatterSummary1 Introduction2 Background3 Identification and Evaluation of the Evidence Base4 Mefloquine5 Tafenoquine6 Atovaquone/Proguanil7 Doxycycline8 Primaquine9 Chloroquine10 Improving the Quality of Research on the Long-Term Health Effects of Antimalarial DrugsAppendix A: Public Meeting AgendasAppendix B: Invited PresentationsAppendix C: Epidemiologic Studies That Met the Committee's Inclusion CriteriaAppendix D: Committee Member and Staff Biographies

Among the many who serve in the United States Armed Forces and who are deployed to distant locations around the world, myriad health threats are encountered. In addition to those associated with the disruption of their home life and potential for combat, they may face distinctive disease threats that are specific to the locations to which they are deployed. U.S. forces have been deployed many times over the years to areas in which malaria is endemic, including in parts of Afghanistan and Iraq. Department of Defense (DoD) policy requires that antimalarial drugs be issued and regimens adhered to for deployments to malaria-endemic areas. Policies directing which should be used as first and as second-line agents have evolved over time based on new data regarding adverse events or precautions for specific underlying health conditions, areas of deployment, and other operational factors

At the request of the Veterans Administration, Assessment of Long-Term Health Effects of Antimalarial Drugs When Used for Prophylaxis assesses the scientific evidence regarding the potential for long-term health effects resulting from the use of antimalarial drugs that were approved by FDA or used by U.S. service members for malaria prophylaxis, with a focus on mefloquine, tafenoquine, and other antimalarial drugs that have been used by DoD in the past 25 years. This report offers conclusions based on available evidence regarding associations of persistent or latent adverse events.

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