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By: (Author) Ariel Alonso , (Author) Geert Molenberghs , (Author) Leacky Muchene , (Author) Marc Buyse , (Author) Nolen Joy Perualila , (Author) Theophile Bigirumurame , (Author) Tomasz Burzykowski , (Author) Wim Van der Elst , (Author) Ziv Shkedy
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An important factor that affects the duration, complexity and cost of a clinical trial is the endpoint used to study the treatments efficacy. When a true endpoint is difficult to use because of such factors as long follow-up times or prohibitive cost, it is sometimes possible to use a surrogate endpoint that can be measured in a more convenient or cost-effective way. This book focuses on the use of surrogate endpoint evaluation methods in practice, using SAS and R.
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