In this compilation, the role of liquid chromatography, mass spectrometry and chemometrics for the analysis and characterization of plant natural products is addressed. The authors provide a comprehensive review of the pharmacological activity of cetrarioid lichens and their major secondary metabolites as antioxidants to prevent and treat oxidative stress-related diseases. Following this, the way in which the detection of various secondary metabolites and bioactive compounds in some plants can reduce sickle cells in vitro is studied. In addition, the efficiency of green and conventional solvent systems concerning the three classes of phytochemicals (phenols, alkaloids, and flavonoids) is described. Lastly, a brief history of antibiotics and the spread of resistance is provided, and future strategies to combat drug-resistant microbes are discussed.
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